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nyquil bomb 

a mixture of half nyquil and half tequilla in a shot glass that f*cks you up if you take enough of them!
Hey, "lets go make some nyquil bombs and get laid out"...
"okay man lets do it" WOOOOOO
nyquil bomb by melvin starkskey February 4, 2007

NyQuil on the rocks 

NyQuil in a glass with ice. For when you're feeling sick but sociable.

Coined by Mitch Hedburg.
I've got a cold but I still want friends over tonight. Maybe I'll make myself a NyQuil on the rocks.
NyQuil on the rocks by KNICKLS April 3, 2009

Nyquil Hangover 

The awful feeling of grogginess during the morning after you've taken Nyquil
"You feeling ok man?"
"Yeah I've just got a crazy Nyquil Hangover"
"Well take it easy buddy, you look like shit"
Nyquil Hangover by amarsten September 19, 2011

Negro Nyquil

(adj) the feeling of sleepiness and happyness shortly after a big meal containing either fried food or dark liquor; meals usually eaten at a family gathering or celebration of some sort. (syn) the Itis.
I just smashed like 3 plates of that gumbo and mac n cheese shoot I'm about to kill this second glass of henn so I can pass out in the car on this negro nyquil.
Negro Nyquil by Phoetykft November 28, 2011

nyquil-coma 

That moment, about thirty minutes after finishing a bottle of nyquil, where you start to feel really sleepy and loopy and then you pass out for ten hours.
"Man, I passed out last night"
"Yeah, why's that"

" I took a bunch of nyquil and fell into a nyquil-coma"
nyquil-coma by Icarus Deidus October 28, 2013

NyQuil Challenge 

Drink 10floz(1 bottle) of Vicks NyQuil or 2 bottles for nightmare difficulty, and then quickly try to masterbate before you fall asleep. If you succeed you win!
I got about 20seconds into the NyQuil challenge on nightmare mode before losing, but I was already tired when I started.