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nuke it from orbit 

One step up from kill it with fire, usually followed by the phrase "it's the only way to be sure."

A paraphrasal of Ripley's line in the 1986 film 'Aliens': "I say we take off and nuke the entire site from orbit. It's the only way to be sure."

Generally used in response to a clusterfuck, or anything largely weird or gross that needs killing or otherwise dealing with.
Mike: Guys, termites have invaded my house, what should I do?
Dave: Nuke it from orbit!
nuke it from orbit by mush01 August 27, 2008
Related Words
-What are you eating?
Yesterday's pizza.
-Did you nuke it?
Yeah, 30 seconds is good.
nuke it by QWERTY1 September 7, 2007
The name of a map in Call of Duty: Black Ops. This map is the smallest map in the game, so it does have some diehard fans. Definitely the most popular map in the game. With gamplay with a good mix of CQB and medium range combat, this map has all the action expected.
I played on Nuketown yesterday and pwned..........
Nuketown by MW2 Freak January 9, 2011
A victorious person. Overcomes all obstacles.
She never gives up on what she puts her mind too.
Has a beautiful heart and would give her last.
I wish you were just like Nakeita!
nakeita by phenomenon1324 July 3, 2015

Nuketown Lobby 

In Call of Duty Black Ops, when players in a lobby use the option to vote for the previous map to repeatedly select Nuketown.
Good Nuketown player: Alright, this is the third game in a row I've gotten my gunship! I love Nuketown lobbies!

Bad Nuketown player: They're voting for Nuketown again?! I'm out, this must be a Nuketown lobby.
Nuketown Lobby by 1337Vivian November 18, 2010
Microwaving food for an extra long time to compensate for it being out of date and/or of questionable quality.
Dan:- "Is that pizza going to be ok? It's been there since Friday"

Matt:- "I'll nuke it to be sure"
Nuke it by Stern Boller August 5, 2011