When someone has massive pock marks on thier face. Compared to the rough pitted surface of a buffalo nickel.
"She has a hot body except for the buffalo nickel face!"
by champion April 17, 2006
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Dope - meaning a stupid person
Face - meaning IN THE FACE.
Nickel - meaning a metal coin worth 5 cents.
Brain - meaning control center of central nervous system.

One of the worst insults in the decade.
"Shut up you, dope face nickel brain!"

"Fuck you, dope face nickel brain!"
by KILL BILL ROSE January 16, 2010
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