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Nature's call 

noun A term used to define, in a G-Rated dialect, the urge to take a massive dump.
1. Jimmy: You don't look so good. What's the rush?
Timmy: I have to answer nature's call!

2. Kimmy: Hey, what's up?
Bimmy: One moment, nature calls.

nature's call 

I awoke to nature's call in the middle of the night.
nature's call by Light Joker January 22, 2007

roadside nature call pitstop 

A term in which during a road trip in the middle of nowhere when a person has to go & there is no rest areas nor travel centers around for miles.
Mom: Stop the car! Little Timmy has to go!!

Uncle Ray: Well looks like we got to make a Roadside nature call pitstop since there is not anything around for miles!

answer the call of nature 

an evacuation of waste matter from the body.

Often described as:
Taking a piss or taking a shit
Bob: Excuse me I need to answer the call of nature.
*Bob gets up and walks away*
Jim: (to George) Where is Bob going?
George: To take a piss he said.
Jim: You sure he didn't mean take a shit
George: I could give a fuck less Jim.

Conference call of nature 

When someone responds to the call of nature during a work-related conference call. People must take great care to mute their phone during said act or risk professional embarrassment.
You were extremely quiet during the conference call?
Yeah dude, Conference Call of Nature
Conference call of nature by crc5654 September 24, 2011

Call of nature 

A polite way of proposing your needs of using the wash room!
Girl: Hey I have to answer the call of nature!
Girl 1: Can I come
Girl 2: Let's go
The rest of the girls: Ya! LET'S GO TOGETHER!!!