(v)--To completely screw a situation or action.
Originates from a tiny, cold, furry little creature lurking about in east tennessee. This creature is adept at climbing and shivering to keep its small body size a little warmer.
"dude, why didnt you have sex with her last night?"
"it just wouldn't work, man. I swear I was sick...I even went to the emergency room."
"you totally Moxley'd that up, fatso."