Derived from the book, "Of Mice and Men" mouse can refer to someone dumber than Larry, particularly a blonde skank who thinks shes smart, but is dumb as fuck. A mouse often make damickey or outrageous comments that once made, are instantly used to pick on said mouse. The mouse typically makes friends with the smartest person in the nearby vicinity(The George of the situation), as it could not survive on its own. (What a dumb bitch). As we know, even with a smart friend, Larry eventually will be killed. Therefore, we can conclude that the mouse is worthless, and should be removed as soon as possible.
Guy 1: That girl that sits behind you in Calculus is so dumb.
Guy 2: Yeah, she is such a mouse.
Mouse: What't a mouse?
Guy 1 + 2: Nothing you fucking slut.

Later that day:

Mouse: George, I don't understand.
George: That's because you are a mouse.
Mouse: No, I am a female.
George: Shut the fuck up... Mouse.
by TeamDank February 20, 2013

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Mouse: a small-boned hardcore kid, who spends his time being nice to people's computers and seducing thse that are sleeping.
geez, did you see the horrid carnage mouse did to the singer of Walk a Mile's computer? that thing went to hell in a basket...
by XbloodXandXcookiesX April 17, 2004

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Plural for the word Mouse. More than one mouse, often used to define mammals, but can also be used to refer to more than one computer mouse.
I have 3 pet mice. I have 10 computer mice.
by Lino Alibani September 22, 2005

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A small-block Chevrolet V8 engine. The first mouse was the 265 inch engine of 1955. The largest mouse was 350 inches.

Compare with Rat.
My truck has a mouse motor.
by Bumkicker Slade May 10, 2005

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1)A type of animal.

2)A device on a computer used to move the cursor.

3)Vagina
1)Today we went to the pet shop and got a pet mouse. I named him Mickey.

2)Oh no, my mouse is broken! Now my cursor can't move and I can't click anything on the computer!

3)We got to see a mouse is sex ed.
by Newbia June 23, 2004

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word used to desribe a senior boy who mouses out who hits on a freshman girl since he is unable to get anyone in his own grade
high school --> senior mousing on freshman
senior is a mouse to freshman girl
by Lebron James/Nikki Minaj February 23, 2011

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The act of tea bagging while fully erect.Dropping ones balls on anothers head or shoulder while "hard". Thus creating a long shaft or "nose"and floppy ears resembling those of a mouse.
You have just been moused by your buddy.
by Daeg Odinson November 17, 2010

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