Term from the British comedy series The Mighty Boosh, Season 2. Used in the episode "The Legend of Old Greg." Basically a kid-friendly version of motherfucker.
Howard: That's not my fishingline Greg: It's attached to your rod, motherlicker.
Another word for motherfucker, but instead your so wasted and high that you don't even give a damn fuck no more about how you look or do because white girl over there got you hammered and banged you in the club while your cussing your friends/nightstand the fuck out...
Tony: Sorry man, I was watching tons of porn on your laptop and now it has viruses everywhere
Jack: You ugly ass motherfucka, this is the 2nd time already dammit!