Top Definition
To open ones mind like a Safe.
You forgot your Mindknob... oh here use mine so I can see whats inside.
by TwistedSnake aka: Mr Karma July 13, 2005
Mindknob is a knob of brain tissue that when touched, causes extreme mental arousal.
Dude, did you see her mindknob?
-No, dude, but I got a sweet case for my Rio Karma thanks to Mindknob.
by n00bixcube June 28, 2005
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