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1.
Mushroom-like testicle
Kid 1: You're a dumbass!
Kid 2: Atleast I don't have a mesticle!
Kid 1 runs away crying.
by tyler the mesticle July 20, 2009
 
2.
Fan of the band Mest (see also, Tony Lovato, Nick Giggler, Jeremiah Rangle, and Matt Lovato)
I am a Mesticle for life.
by Ashweed October 10, 2004