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When you are afraid of something, but you don't know what it is. Used in the novel and movie, Breakfast At Tiffanys.
...the blues are because you're getting fat or because it's been raining too long. You're just sad, that's all. The mean reds are horrible. Suddenly you're afraid and you don't know what you're afraid of.
by Missy January 11, 2005

Words related to mean reds

cheerful girl happy laugh sunny custard yellows
Really, really, really, bad.
"Deirdre, that trucker cap is mean-red."
by Hamish Robertson October 16, 2003
Period, as in a girl's period.
Guy 1: So how's your sex life?
Guy 2: No good, my missus has the mean reds...
by winaje May 05, 2005