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1.
When a man is going through his monthlies
"You are a bitch right now - are you on your manstration?"
by Jeremy W September 12, 2005
 
2.
when a man is in a particularly unpleasant mood, for no appearant reason.

A short tempered man
The male term for PMS, or bitchiness
Kyle: Dude just shut up already, you're annoying the hell out of me.

Sammy: Would you like me to get a tampon for that manstration?
by Ima Crazy Bitch August 15, 2009
 
3.
The irrational periods of anger that all males will experience at least once. Usually lasts 24-48 hours.

It is believed to be due to a random influx of testosterone in the male's body. It is the driving force behind all creation, all civilization, and all invention.
_______________________________
Symptoms include, but are not limited to:
-Wanting to punch inanimate objects for no specific reason
-Pulsing headaches that can only be treated by punching things
-Voracious hunger, best remedied with large quantities of steak.
-Excessive swearing
-Excessive drinking
-Insomnia/Narcolepsy
-Agoraphobia/agoraphilia
-Photophobia/photophilia
-Periods of intense intelligence/ambition followed by periods of ignorance/lethargy
Julianus: Shit bro, I'm manstrating hard. Wanna build an empire to fuck shit up?

Romulus: Sure man, creating an empire that has a big ass legion must be the equivalent of punching dozens of inanimate objects.

Julianus: True shit. That's one of the best cures for Manstration.
by Bando-De-Shamrock May 29, 2013
 
4.
when a man is in a particularly unpleasant mood, for no appearant reason.

A short tempered man

The male term for PMS, or bitchiness
eg: w loots - manstration
by synergyxcoza January 14, 2011
 
5.
When she just got back from a week at her grandmother's house and hasn't been touched in forever so you just take one for the team and after like the sixth time in a half hour that you've cummed it doesn't even feel good at all it's just incredibly painful but you keep going because she's still horny and finally on the seventh time when your dick is just shouting out "STOP STOP" you have a weak hellaciously painful nothing of an ejaculation and realize that blood just came out your dick.
Doctor: You've ruptured your vas diverenze, seminal vescicals, popped one testical and backed up your epididimus with coagulated blood and seman. if you have sex again in the next year you will die. How did this happen?

You: Manstration
by The Lonliet Monk December 31, 2007
 
6.
Male masterbation.
Yesterday's hot weather really inspired some "manstration".
by DiscoDuck August 18, 2009