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1.
The act of getting a manicure and a pedicure at the same time.
"My friend gets mani-pedis all the time, but I refuse to demean some poor woman by making her scrape my feet. Also, I don't like somebody weird touchin my feet."
by Nastina August 06, 2005
 
2.
manicure and pedicure, having your finger and toenails polished and treated.
Steve went to the nail salon for his first mani-pedi today.
by King_Smirgel July 08, 2013