8
An STD received by striking out with a fat chick for quite some time
Beckeltron got mad cow
by Aflac March 23, 2004
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9
A diesese which is carried through the air and turns cattles brain to the same mush your grandmother eats at her old folks home. Remember the best way to combat the diesese is to wipe front to back at all times.
Young Hick Boy: "I think that ma's sick pa'

Hick Farmer: "I reckon shes got madcow, time to close the border again (spits tobacco)"
by Schefter January 01, 2005
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10
When you don't treat a cow right. Meaning you don't yank on its tits.
Go yank on that mad cow's tits
by The clit commander April 10, 2003
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11
A soccer momwhen she discovers that her husband's been cheating on her with his secretary/president, or when her kids are accused of something, like shooting up their school because they ran out of Froot Loops. Basically,a fat, angry irrational woman.
When they announced that Mrs. McMooney's son was the one who called in the bomb threat at the mini-mal, she went into full-on Mad cow mode.
by Shawn B. May 03, 2003
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12
I came home drunk and the wife started screaming at me like she had the mad cow!
by Ted W. April 25, 2003
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13
A shot consisting of 1/2 Sperm, 1/4 Vodka, 1/4 Jack

You can tell someone its milk if you want to...
"Dude, Sherry just totally did a Mad Cow...shes so stupid.
by pool boy September 19, 2007
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14
an obese unkept female who is generally found in sweatpants, gets jealous over the hottie/honey dip in the room that her man can't take his eyes off of, sometimes resulting in obvious bickering between the couple who leave the area shortly after the incident. Therefore she becomes a "mad cow" also known to be found happening with skinny ugly girls who have no boobs or personality and buck teeth, bug eyes , etc.
Madcow: has look of hate and eating chicken fried steak with mashed potatoes and gravy watching husband every eye movement and says nothing

Husband : can't control himself and incessantly stares while drooling at hotties taute firm ripe ass- leaves with raging hard on.

<mad cow > < Mad > <cow> <Madcow disease>

Honeydip to friend ; look! that Madcow and her man r leaving now
by Space cowgirl68 March 31, 2013
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