To engage in sexual activity with someone, or as the kids say these days, to hook up.
Basically you hundo p are getting frisky with someone.
Sammy: You going to Jen's tonight?
Noah: Hell Yeah! You know I Mack Up
Sammy: Aight Bet!
by weiny0402 November 10, 2018
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To repeatedly fire a .50 caliber weapon (such as the .500s&w, .50BMG, 50-70, .50AE etc) in the air several times to wake somebody up or get their attention much like Richard Machowicz when he fires his .50 caliber weapons on the badass tv show "Future Weapons".
*Kyle and Joe at the shooting range*
Joe: kyle!
kyle: ...........
Joe: KYLE!!!
kyle:........
Joe: *fires desert eagle 4 times*
kyle: ahhh!! what is it!!
Joe: apparently you needed a mack wake up to get your attention.
by Ekim_ October 31, 2010
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