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Informal for marijuana
Yo, that locoweed is tripping!
by t352=458963490670 December 07, 2010
another name for datura, a psychoactive, hallucinative and poisonous plant found in many temperate climates throughout the world. it first got the name when settlers in virginia ate it and "went crazy". truth be told, it is a toxic nauseating plant, but you will trip balls if you take it: its just gonna be incredibly intense and often unpleasant.
yo man try this shit out, its loco weed, you're gonna go nuts

by fljflkjsdf October 24, 2007