another name for datura, a psychoactive, hallucinative and poisonous plant found in many temperate climates throughout the world. it first got the name when settlers in virginia ate it and "went crazy". truth be told, it is a toxic nauseating plant, but you will trip balls if you take it: its just gonna be incredibly intense and often unpleasant.
yo man try this shit out, its loco weed, you'regonna go nuts
A hardo is a person who tries extremely hard at everything. Most times a hardo will try very hard at things that do not require excessive effort. For example, sports practices, gym class, etc.
Wow did you see Jack at practice today? What a hardo!