Top Definition
Agitated, anxious, in a tizz. British, Strine, and New Zealand. Cf. panties in a knot.
Don't get your knickers in a twist. The Frogs are just that way.
by Octopod November 07, 2003
Upset or stressed about an issue or situation
the criticism from her boss really put her knickers in a twist.
by Scootb May 21, 2015
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