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1.
1. Klinefelter's Syndrome: Having two X chromosomes and a Y chromosome (XXY), leading to physical defects such as being exessively tall, overweight, having enlarged male breasts, and small (2cm) testicles.

2. An extremely offensive/hilarious way of pointing out that you find a female to be unnatractive by fault of her overall brute masculinity.
guy 1: why is that chick wearing football gear?
guy 2: ugh, those are her shoulders. she's definitely got the klinefelters.
guy 1: i think i'm going to be sick.
by truffer hoffer December 16, 2005
25 20
 
2.
A nickname for the drink commonly referred to as "Red Bull & vodka"
Hey, barkeep! Get us a round of Klinefelters, wouldja?
by chagrin94 November 13, 2009
3 6
 
3.
a man who has a small penis and big man boobs
yo nigga dat dude justin brands is such a klinefelter
by Joey June 06, 2004
27 30