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Jacksepticeye Syndrome 

When you yell and scream over everything.
My friend got Jacksepticeye Syndrome after I beat him in a game.

jacksepticeye 

a sweet, humble, and good little irish bean in brighton. jack is always trying to be his best, while inspiring others to do the same. PMA!
"Dude do you know Jacksepticeye?"
"yes of course, you fish."
jacksepticeye by trashnerd42 May 27, 2018

jacksepticeye 

A very loud irish youtuber. He is also the BOSS of BOSSNESS! Having over one million subscribers on youtube, he keeps a close connection to his fans. Did I mention he is BOSSSS?
"Jacksepticeye is BOSS!"
jacksepticeye by TinyToni October 25, 2014

Jacksepticeye mood 

When you feel like you want to see S*** explode
Guy1: Im in such a jacksepticeye mood today,
Guy2: Just come to my place, i have some grenades
Guy1: why do you have grenades?
Guy2: because im always in a jacksepticeye mood.

jacksepticeye 

Jacksepticeye is a amazing youtuber from ireland and he has over 4 million subscribers. Jack has helped a lot of people during rough times, he is very loud, he calls himself THE BOSS or BOSSOTRONIAN, Jack tries to communicate with everyone of his veiwers, And he loves his fanbase and will not stop any time soon, (^-^) he is hilarious too.
"if you dont watch jacksepticeye i kill you (im joking btw) he is awesome
jacksepticeye by HTETYD May 11, 2015

jacksepticeye syndrome 

When someone, usually when gaming, yells and screams at their screen. They're normally loud but doesn't have to be to class as jacksepticeye syndrome. Not to be confused with anything about loving jacksepticeye or being a fan.
My friend got jacksepticeye syndrome when I beat him in a game.