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jacked up 

This is a phrase largely equivilent to fucked up or screwed up. It roughly means "in a state of disarray" and is commonly used in the phrase "to jack someone/something up". In some cases, the meaning may be slightly altered by the fact that to get "jacked" can mean to be struck or injured.
That's jacked up man. I can't belive your girlfriend is cheating on you.

I got in a wreck last night. My car got totally jacked up.
jacked up by pete August 12, 2004

jacked up 

1. not working properly or as intended.
2. having used a large quantity of speed, cocaine, or other amphetamine.
3. cut or lacerated by means of a make-shift knife or blade. see SKIV
4. In generally poor or injured condition.
sense "1": "This is so JACKED UP! She said she'd be here at eight!"
sense "4": "I want to play, but my shoulder's still JACKED UP from last weekend.
jacked up by mainframe October 31, 2003

jacked up 

In the military, to be given a stern talking-to by an NCO for some offense or omission.
"We all got jacked up this morning for calling him 'sergeant-major' instead of RSM."
"On course they'll jack you up if you aren't wearing dress uniform in your ID photo."
jacked up by HellHound May 6, 2015

jacked up shit 

That is some jack up shit yo!
jacked up shit by Jessica Grimes January 7, 2005

Jacked Up Grill 

1. One's teeth/smile that is in need of dental work.

2. One's teeth/smile that is in poor or injured condition.
Jacked Up Grill by Rosalinda February 7, 2005

Jacked up kidney top 

Pheochromocytoma, a tumor of the adrenal medulla causing it to secrete large amounts of epinephrine and norepinephrine.
"My patient in room 214 has a jacked up kidney top so I had to prescribe her phentolamine."