Top Definition
The state of being completely sick of lame-o's that think they're adorable. Commonly mistaken for being obsessed with such people.
Dude 1: I have a serious case of ireneitis...
Dude 2: Do you mean like you can't get enough of girls who think they're amazing but really aren't?
Dude 1: Naw man, you're stoopid. I'm COMPLETELY sick of those types...
by Goober Extraordinaire May 23, 2009

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