Top Definition
Something that is beyond normal amount of crazy; from the Cypress Hill song "Insane in the Brain"
Man 1: I'm getting my spine pierced later.
Man 2: That's insane in the membrane!
by thegestalt August 28, 2005
Smoking some of that good chronic and it's hitting you hard making you; insane in the membrane.
"Dude, I was just listening to some Cypress Hill puffin on a fat blunt of OG Kush and now I'm totally insane in the membrane. Shit hit me hard man!"
by PsycobetabuckdowN December 04, 2014
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