Something that is beyond normal amount of crazy; from the Cypress Hill song "Insane in the Brain"
Man 1: I'm getting my spine pierced later.
Man 2: That's insane in the membrane!
by thegestalt August 28, 2005
defines something beyond crazy
"dude, thats insane in the membrane"
by Allison September 23, 2004
Smoking some of that good chronic and it's hitting you hard making you; insane in the membrane.
"Dude, I was just listening to some Cypress Hill puffin on a fat blunt of OG Kush and now I'm totally insane in the membrane. Shit hit me hard man!"
by PsycobetabuckdowN December 04, 2014

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