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1.
Something that is beyond normal amount of crazy; from the Cypress Hill song "Insane in the Brain"
Man 1: I'm getting my spine pierced later.
Man 2: That's insane in the membrane!
by thegestalt August 28, 2005
 
2.
defines something beyond crazy
"dude, thats insane in the membrane"
by Allison September 23, 2004