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1.
A prediction or educated-guess based on current evidence that is yet to be tested.
I hypothesize that my pants will decend.

It seems that my hypothesis was correct. Now, to get funky.
by Didda Tinkle June 06, 2004
 
2.
An hypothesis is "a proposition, or set of propositions, set forth as an explanation for the occurrence of some specified group of phenomena, either asserted merely as a provisional conjecture to guide investigation (working hypothesis) or accepted as highly probable in the light of established facts." Which means that not all hypothesizes are the same. I can hypothesize that the wind might blow a kite I'm holding to the right if the wind starts blowing in that direction but that would be a guess. I can also hypothesize that life arose from nothing but that would be completely speculative and guess-work.
An hypothesis in science can sometimes have some established facts but can otherwise be entirely guess-work like the abiogenesis hypothesis which is fueled entirely by the blind faith of atheists.
by Skialian January 09, 2014
 
3.
According to Dictionary.com, an hypothesis is "a proposition, or set of propositions, set forth as an explanation for the occurrence of some specified group of phenomena, either asserted merely as a provisional conjecture to guide investigation (working hypothesis) or accepted as highly probable in the light of established facts." Which means that not all hypothesizes are the same. I can hypothesize that the wind might blow a kite I'm holding to the right if the wind starts blowing in that direction but that would be a guess. I can also hypothesize that life arose from nothing but that would be completely speculative and guess-work.
An hypothesis in science can sometimes have some established facts but can otherwise be entirely guess-work like the abiogenesis hypothesis which is fueled entirely by the blind faith of atheists.
by Skialian January 09, 2014
 
4.
A guess made by someone with a PhD.

In common usage, the words hypothesis, model, theory, and law have different interpretations and are at times used without precision, but in science they have very exact meanings. A hypothesis is a limited statement regarding the cause and effect in a specific situation, which can be tested by experimentation and observation or by statistical analysis of the probabilities from the data obtained.
It's not just a guess, it's a hypothesis.
by Bill Gronos July 04, 2006