Top Definition
A male individual in one's friend or acquaintance group who is

1.) extremely elated by the state of his life or
2.) inebriated by a chemical substance, especially THC (delta-9-tetrahydrocannabinol found in marijuana).

This person is usually experiencing an elevated or merry mood and tends to act in a mellow and detached manner. A hybro may often act as the life of a party and elevate the mood of the people who surround him.
My friend smoked a lot of marijuana and quickly turned into a hybro.
by HYBRID_UNIT March 10, 2011
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