look up any word, like wyd:
 
1.
used as a question to ask how a person is doing, or how you do somthing
gangsta_1: how it do?
gangsta_2: Goooooood, getten me some sweet poon tang
gangsta_1: foshizle?!
by cloak and dagger December 18, 2005
 
2.
what's up, how's it going?
often used to mock those who greet with "what it do?" or "what it is?" by using even worse grammar.
"How it does?"
"Hello. Man you talk stupid!"
by k streezy April 05, 2009
 
3.
Can be used as a substitute for any question including why, how, or anything else. Made popular by Captain Jack Sparrow, played by Johnny Depp, in Pirates of the Caribbean.
"How it do?"
"You take the inverse cosine of theta and multiply by 2"

"HOW IT DO?!?!?!?!?!!?!"
by Kenny Eng January 28, 2010