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To have or cause to have emotional difficulties or inhibitions
You have not been yourself today. What's your hang up?

Hang up the guns 

To Retire, settle down.
It's based on the idea of an old gun slinger who finds true love and 'hangs up his guns' to become a farmer.

In modern usage, it could be said about a guy who has previously had lots of casual relationships, or considers himself a 'playa'
"I tell ya man this chick is sooo sweet!"
"So you gonna hang up the guns?"
"Holstering my weapon as we speak"
"Mug!"

hang up the phone 

An annoyed or embarrassed response to the stupidity or incompetence of another. Synonymous with "Shut the fuck up", or "Jesus, you're stupid". Derived from one man's inability to counteract the obliviousness of those around him, to which he blurted it out in frustration. Also, an appropriate reply to an unfunny or otherwise retarded joke.
Bo: "Boy, I have a lot of tools in my garage."

Me: "Hang up the phone, tubby."

hang up and drive 

What is shouted at the moron driving a 4000 pound motor vehicle and attempting to talk or even text on their cell phone while in motion. These are usually people that cannot multi-task but are either too vain or ignorant to realize it. They are in need of support from the community to let them know what they are doing is going to get someone killed. This is done either with a middle finger, an angry look, a colorful suggestion in a loud voice or a bumper sticker telling them to "hang up and drive." Once being made aware, they should terminate their call immediately and put both hands back on the wheel and pay attention to traffic conditions.
"Hey, you just drifted into my lane because you are driving with your elbows while texting... HANG UP AND DRIVE!"
hang up and drive by Mojo12 August 11, 2009

hang up and hang out

Used when a friend pulls out their phone among a group setting and fails to interact with fellow peers.
*friend pulls out phone during a group conversation*

"yo dude, hang up and hang out man"

Fuck You *Hang Up* 

The only pure way to kill off a phone conversation with you having the last word.
John: You're a dick

George: Well, i fucked your Mum!

John: Fuck You *Hang Up*