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1.
Short for "half ounce" usually in reference to a half ounce of marijuana.
Wigger 1: Damn nigga you got a half o in your bag!

Wigger 2: Maaan that aint shit, I be tokeing half o's by the day
by G ram June 28, 2006
 
2.
A half ounce (14g) of ANY illicit drug. Usually used describing weed or cocaine amounts.
G-money-"I just got my issue today mayne"

Killerfred-"how much you got nigga?"

G-money-"just a half-o, lets get crackin"
by Shweetbox July 16, 2005
 
3.
A half ounce of Chronic
Yo i just got a half o lets go blaze
by Rusty February 17, 2005