Another slang term that Anthony uses out of randomness. See also: man's ass
Ex1:
Guy: Ok. So as I was saying....
Anthony: Wait! Dude! Two guys?

Ex2:
Anthony: Dude....of all seriousness...two guys.
by Justin W. June 9, 2004
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Not a porn video, just 2 guys casually chilling in a hotub but obviously 5 feet apart and continuously say "dude I'm not gay, I'm so straight" to ensure everyone is made clear about their sexuality.
Ben: Dude sitting in this hot tub doesn't make us gay right?
Jim: we're just two guys in a hotub we just need to mention our sexuality every 5 seconds.
by MemeLord17 June 24, 2017
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Popular alcoholic shot known to be enjoyed by loose women made up of one part Jack, one part Jose and one part green apple schnapps.
Susie had more "Two Guys At Once" last night than should be legally allowed.
by TS Regpark February 18, 2010
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two guys and the trailer is a joke.
one time there were these two guys and they saw a long line of men lined up at a trailer and a sign on it said 25 cents.
one guy said whats that line for? the other said I don't know give me a quarter and I a find out. so he took the quarter and waited in line.
when he got to the trailed a woman took his quarter fucked him and kicked him out the other door.
the other guy said to him so what was it? the guy said I don't know but you got another quarter?
did you hear the one about the two guys and the trailer?
by Deep blue 2012 August 29, 2009
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A joke.
There was this woman who was getting fucked by a lot of guys.
Her husband said if you let anybody fuck you again I'm going to pull all the hairs out of your pussy.
then a white guy came to see her and started fucking her.
Then she said somebody's coming quick hide in the closet! so he hides in the closet.
Then this black guy comes in and starts fucking her.
Then she said somebody's coming quick hide in the closet!
Then her husband came in and said has somebody been fucking you AGAIN !
so he pulls all the hair out of her pussy except one.
as her starts to pull the last hair out of her pussy he said come out of there you little black s.o.b.
then the black guy speaks up and said not before you make that little white s.o.b. come out first.
by Deep Blue 2012 August 17, 2009
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