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1.
Def 1. From the 1999 film The Matrix: Referring to a human experiencing déjà vu as caused by the Machines altering the Matrix.

Def 2. An explanation for an unlikely or irregular occurrence.
Ex 1. Neo identified a glitch in the matrix when he saw the same black cat walk past the door twice.

Ex 2. There must be a glitch in the matrix because I was struck by lightening and won the lotto all in the same day.
by dictionaryname February 24, 2009
 
2.
A phenomenon that potheads use to explain things that happen when they have no idea (usually because they are stoned).
Dude, I found my lighter in the cabinet! Talk about a glitch in the matrix!
by suburbanite November 29, 2003
 
3.
When, in short period of time, you see pairs of cars, passing by, matching in color and brand, identical. Not just one pair, few. And not even the common brands, but those that you never happen to see two of the same brand in the same place.

Surely the matrix glitched somewhere there. No other explanation. Nah-ah.
"Err, dude? I think there's a glitch in the matrix. Look at the road - !"
by Elizabeth_Bathory January 11, 2010
 
4.
an account for a missing period of time or a lapse in the space-time continium.
usually used by stoners and those without the brain capacity to remember what they had for breakfast.
G1:"you guys seen my dog?"
G2:"no, didnt you leave him at K-mart?"
G1:"when??.........oh shit!"

C1:"uhg ug!"
C2:"ug uhh guh?"
C3:"when??"
by hex_ten December 01, 2003
 
5.
Hiring Keanau Reeves to play the lead role
The only glitch in the Matrix is the lack of acting on the part of the main character
by Jonesys November 09, 2004
 
6.
When something in changed in the matrix. In laymens terms when things go tits-up.
Ah get of yer ass and watch the film!
by Mortuus February 02, 2004
 
7.
Essentially, a term referring to a retard. derived from the movie "The Matrix." also referring to degenerates.
Man, that glitch in the matrix plays with his own shit like it's Play-Doh.
by zach greg May 07, 2006