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1.
(Mostly phrased to women)To tell a person to go wild,crazy and to do anthing....and that means anything!
"Like dem girls on dat Tip Drill video"... "Let me see you get loose!!!"

-T.I.feat. Nelly
Get Loose
by Kevin Jones January 27, 2005
 
2.
getting nasty and doing anything sexual
yo mama get loose for a dub
by ezzy22 May 06, 2010
 
3.
the act of consuming grey goose
"you wanna get loose?" interpretation "you wanna drink some grey goose and get f'd up?"
by ghetto vaquero December 30, 2005