You will say this when you question what is asked or told to you in the most extreme way possible.

Usually you would say "are you kidding?" in a subtle way if your calm but when you become full on angry, angrier that Goku...; ARE YOU FUCKING KIDDING ME?!?

basically...this can be said at any given time when someone asks you a favor, question, a "go do it" order.
Hey I forgot my bag at home can you drive 20 minutes over to drop it off

ARE YOU FUCKING KIDDING ME?

(Almost at the end of a Halo game, Iron being on..and everyone dies) ARE YOU FUCKING KIDDING ME?

(Power goes out when you are downloading super important shit) ARE YOU FUCKING KIDDING ME?
by ...their not fucking kidding.. October 14, 2011
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A mixture of "are you fucking with me?" and "are you serious?" commonly used when cut off by some dumbass driver, who was too stupid to get over when they were supposed to.

Also when you hear something completely unbelievable.
A stupid Honda cuts you off, almost causing you to text-end so you scream "are you fucking me seriously?"

"honey, I think were have sextuplets"
"are you fucking me seriously?"
by tinkmobile June 21, 2009
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When a manchild gets heavily offended by a 9-year-old's comment. Most famously coined by the Twitch streamer "Ninja" when he took the bait of a little kid in-game.
Ninja shoots 9-year-old
9-year-old: "aw fuck u faggot"
Ninja: "THE FUCK YOU SAY TO ME YOU LITTLE SHIT?"
9-year-old: "HA U RAGE XD"
Ninja: "FUCJKCJXGVIOKFDJGOIKDSMGFKL;SDMFLS"
by That random guy thing December 2, 2018
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Basically when some pisses you off or screws you over aka fucking you in the asshole.
Becky: I spilled your starbucks
Brad: Wtf becky are you fucking me in the ass right now?
Becky: Sorry
by Eisenhower June 25, 2017
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