A shot to the head.

It is said in the tv show Gangland when Do was describing a way to do a hit.
"We had a, uh two guys, we called them Double Trouble. One person would hit you in the body, which would drop you, and the other person would put the what we call the fo sho."
by daboodeef197 September 24, 2011
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a simplified version of the phrase 'for sure', used in a manner like 'nigga' or 'pop a cap in yo ass ho'
Me: 'fo sho, man.'
random black person: 'bitch ass nigga! i aint talkin to u ho! open yo fuckin ears bitch!'
by nixdaboss November 20, 2011
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'hip' word for for sure. mostly used with sarcasam
person1: i hooked up with jessica alba last night
person2: fo sho and i had sex with the queen

{sarcasam used}
by random-persons September 10, 2006
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Stating that you are "for sure" going to do something. It is definate and without a doubt (that is why it is stated twice in a row).
Known from the character Seth in the popular teen movie Superbad, where he tells Jules that he will "for sure" buy alcohol for her party.
"Yeah we're going to the party fo sho fo sho. We're going to the party fo sho."
by shannybanny March 21, 2008
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a girl (or guy i suppose) that is known for being easy. So easy, in fact, that you will "for sure" ("fo sho") be getting laid by them. Also known as a slut.
Dude, i'm so stoked to go out with Suzy tonight; she's a fo sho fo sho!
by shannybanny March 21, 2008
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