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The first time during a long drinking session that one has to finally answer the call of nature or take a piss. This is a bad thing as this generally signals that there will be the beginning of many frequent drink-interupting trips to the dunny.
I held on as long as I could but after five beers I had to take the fatal first piss.
by Busted Hyman July 06, 2006

Words related to fatal first piss

dunny piss bladder break the seal drink drinking toilet urine