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1.
1. (dictionary) Widespread contagion, usually a bacteria or virus, that kills or severly sickens a large number people in a particular geographic area.

2. (American Media) Half-assed drug or dumbass activity that kills a couple suburban white kids, usually in the Baltimore area for some reason.
1. The SARS epidemic of 2003 killed hundreds and hospitalized thousands in China and Toronto.

2. Stone Phillips reporting on the highway surfing epidemic... Ashleigh Banfield to follow with an expose on the paint-huffing epidemic.
by The Evil Steve August 17, 2005
 
2.
A disease that has started killing white people. Until then, it's just a disease, regardless of how many have already died.
AIDS is a disease that started in Africa. But now it's an epidemic that has hit the gay community in San Francisco.
by D3uteron June 05, 2009
 
3.
Awesome general positive adjective.
That's epidemic, dude!
by shdklashdas June 26, 2009
 
4.
Something that is cooler than cool...
That party was 'epidemic' yo!!
by Long Kim Duong and Quoc Phan February 25, 2004