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The word "effers" was derived from some retarded kid by the name of Alor.
The word is usually used to express annoyance, disgust, surprise, anger, irritation, contempt, or disappointment...usually in a light-hearted manner.
(Lately, this word has been favorably used using squinted eyes, a scrunched nose, and a whispery, whiny voice, all while hunching the back slightly and is usually followed by the recipient with the traditional slow shake of the head, a stupid smirk and the low mutter of the word "geek.")
Effers Example 1:
Alor: "Hey Eyuel, Samora forgot Madden at home."
Eyuel: "Effferssss!"

Effers Example 2:
Melaku: "Hey you guys, my mom said we have to leave cuz its getting dark and she wont be able to find me so I have to take the ball now."
Aklil: "But it's only 5:30! You won't disappear until 9!"
Eyuel: "Effferssss!"

Effers Example 3:
Alor: "Hey Joseph, can I borrow a dollar?"
Joseph: "Alright."
Eyuel: "Effferssss!"
Alor and Joseph: "..the heck?"
Eyuel feels stupid.
by Nati T July 20, 2006
A variant of "fucker" used on Canadian television, primarily "Royal Canadian Air Farce". Pre-teens have been known to use it when quoting, should the term "fucker" come up in the quotation.
"Pig effer!"
by Bowman June 16, 2002
mother fucker; bitch/son of a bitch.

An insult.
What an effer.

Yeah. Bitchy like hell.
by frinzee July 17, 2010
B1: I stole your girlfriend, B2.
B2: You Effer! Give her back!
B1: She's effin' hot, and so I won't, Effer.
by SweeetHamm January 02, 2009
Someone who owns you, especially in Counter-Strike, Starcraft, and Reversi.
"Wow that guy sure was an effer!"

"Naw, he wasnt THAT good..."

"Ya, your right, what a scrub."
by First2die March 08, 2003