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1.
A variant of "fucker" used on Canadian television, primarily "Royal Canadian Air Farce". Pre-teens have been known to use it when quoting, should the term "fucker" come up in the quotation.
"Pig effer!"
by Bowman June 16, 2002
 
2.
The word "effers" was derived from some retarded kid by the name of Alor.
The word is usually used to express annoyance, disgust, surprise, anger, irritation, contempt, or disappointment...usually in a light-hearted manner.
(Lately, this word has been favorably used using squinted eyes, a scrunched nose, and a whispery, whiny voice, all while hunching the back slightly and is usually followed by the recipient with the traditional slow shake of the head, a stupid smirk and the low mutter of the word "geek.")
Effers Example 1:
Alor: "Hey Eyuel, Samora forgot Madden at home."
Eyuel: "Effferssss!"

Effers Example 2:
Melaku: "Hey you guys, my mom said we have to leave cuz its getting dark and she wont be able to find me so I have to take the ball now."
Aklil: "But it's only 5:30! You won't disappear until 9!"
Eyuel: "Effferssss!"

Effers Example 3:
Alor: "Hey Joseph, can I borrow a dollar?"
Joseph: "Alright."
Eyuel: "Effferssss!"
Alor and Joseph: "..the heck?"
Eyuel feels stupid.
by Nati T July 20, 2006
 
3.
mother fucker; bitch/son of a bitch.

An insult.
What an effer.

Yeah. Bitchy like hell.
by frinzee July 17, 2010
 
4.
FUCKER!
(F-er!)
B1: I stole your girlfriend, B2.
B2: You Effer! Give her back!
B1: She's effin' hot, and so I won't, Effer.
by SweeetHamm January 02, 2009
 
5.
Someone who owns you, especially in Counter-Strike, Starcraft, and Reversi.
"Wow that guy sure was an effer!"

"Naw, he wasnt THAT good..."

"Ya, your right, what a scrub."
by First2die March 08, 2003