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Based on the popular "Never go full retard" quote, to go dfresh, is to go past the point of 'full retard' as a result of prolonged intoxication.

The characteristics of dfresh are only temporary, however they resembled the behavior and appearance of long-term drug addicts and alcoholics.
"Dude, as soon as the sun rose on Sunday that twisted creep went full dresh"
by Skewtangjewtanghowboutwebang? November 20, 2011
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2
can't speak now, got to dresh on
by patrisha March 15, 2004
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