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1.
Based on the popular "Never go full retard" quote, to go dfresh, is to go past the point of 'full retard' as a result of prolonged intoxication.

The characteristics of dfresh are only temporary, however they resembled the behavior and appearance of long-term drug addicts and alcoholics.
"Dude, as soon as the sun rose on Sunday that twisted creep went full dfresh"
by Skewtangjewtanghowboutwebang? November 20, 2011
4 1
 
2.
Original gangster who stays on the grind 24/7. Straight up hustla who gets crazy amounts of pussy. Hung like a horse.
My boy D Fresh put a slug in the snitch's head.
by Burly Lumberjack December 09, 2009
4 1