A phrase used to make fun of someone after they have done something stupid. Also, a disease similar to mental retardation. Many people who have down syndrome have competed in the Special Olympics.
What the hell is your problem! Are you down syndrome or something?
by J-dog April 10, 2005
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very strange...and exessively weird
cara is the coolest kid with down syndrome i know
by ilovematthew May 8, 2006
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People who have extra chromosomes. Often make jokes that make no sense and have to explain and despite that, the joke still makes no sense. Symptoms are using out of context memes, reselling and having sexual temptations of animals
by Immigrant_Kid March 30, 2020
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an insult, to say to ones friends when they are acting 'crippled'
Clutch, are you fuckin down syndrome!
by 106_joN March 27, 2005
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Many people think that people with Down Syndrome are stupid and look weird. I think the opposite, they are strong and independent and loving and smart people. Their so awesome that everyone should be their friend.

Remember a little kindness cam go a long way.
People With Down Syndrome are Awesome People!
by #LBMF October 3, 2019
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That stage in the night at which you've had too much to drink, partied too hard, danced too much, or drank that one spirit that really puts you on a downer. The syndrome can often be amplified if the patient is going through some sort of trauma or difficulty in his or her (sober) life. The sufferer will also attempt to start deep, meaningful conversations with friends or even unknown passers by, spilling out his or her emotions in an attempt to solve his or her problems. This is usually followed by regret the next morning.
some are more prone than others.
Robert: Hey, why's Joe slumped in his chair, not talking to anyone, on his phone (again)?
Laura: ooohh...yeah I forgot to tell you something about Joe...he's got Down Syndrome. Stay well clear of him.
by joeiles August 31, 2008
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