Southern definition: Meth
Northern definition Heroin
Also dope can mean awesome.
He was cooking dope in his house.
She is a dope whore who sucks dicks to buy more heroin.
That movie was dope!
People who do Marajuanna call Heroin Dope.
Word has also been used to describe how good somthing is.
OMG, I smoke the green but I don't do dope ( AKA Heroin )
Man that car is dope!