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i dont know you from atom 

not knowing someone at all - to be more precise, not knowing someone even at the very infinitesimal atomic level.
"yo brah whuh chu jarking?"

Shit man, i dont know you from atom

you dont know your ass from a hole in the ground 

you know nothing or you dont know what you are doing
sir you dont know your ass from a hole in the ground

I honestly dont know what you are speaking of

What you say when you honestly dont know what somone is talking about.
Eh? I honestly don't know what you are speaking of....

dont know what you been smoking 

Simply means you do not know were one is coming from in the way they are thinking
Tracey: You been gon awhile, you been cheating aint you!?
Trix: No! what are you talking about, dont know what you been smoking but your wrong.

Oh so you dont know what karlson is? 

KARLSON IS JUST A LITTLE GAME IM WORKING OM WISHLIST IT NOW ON STEAM GAMERS
Dani: Oh so you dont know what karlson is? KARLSON IS JUST A LITTLE GAME IM WORKING OM WISHLIST IT NOW ON STEAM BONERS

you dont know rachel 

You have officially fucked up. You have obviously done something hurtful, mean, or just some stupid shit to piss rachel off. There will most definately be a reaction to your action.
Oh damn, you gonna get it now, you dont know rachel!