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1.
A dirty shot is similar to a normal shot of alchohol but involves mixing things together which should not normally be consumed at the same time. Usually, the drinker has to be quite intoxicated already to agree to drinking such shots.
"I was being plied with dirty shots last night, I was completely wasted and even had a vodka and actimel one!"
by quasimojo December 01, 2007
 
2.
A shot of liquor after it has been used as bong water.

Usually performed only as a sign of masculinity, as it won't get the drinker any higher and is actually quite disgusting.
We decided to get creative and fill the bong up with vodka, smoke a bowl, and take a couple dirty shots.
by rob rob69 October 21, 2008
 
3.
and shot of liquor mixed with cumm
jane sucked down 3 dirty-shots last night
by x.d.c. December 21, 2010
 
4.
The Dirty Shot is one of the easiest ways to ruin somebody's night at a party. When you notice your rival has had a bit too much to drink, you replace his/her shot glass with one full of cum. Enjoy as you watch first looks of confusion and then looks of horror.
Bro #1 'dude did you see that asshole matt last night'

Bro #2 'ya i can't beleive that douche took a dirty shot'

Bro #1 'i hope he gets AIDS'
by mattsanasshole September 12, 2008