Top Definition
A disability that causes those it afflicts to be unable to follow even the most simple instructions.
Bill: Dude, wtf!?! You were supposed to pick me up at the airport yesterday.

Tom: For realz? I thought that was tomorrow. My directile dysfunction must be acting up again.
by Jtothebizzy January 23, 2010
When your navigation system isn't working.
I wanted to go to Taco Bell, but my navigation to me to the post office. It must be having directile dysfunction.
by LemonZest June 19, 2016
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