Top Definition
When a male gets overly anxious about an event. Similar to a woman "getting her panties in a bunch".
John: OMG, this is a complete disaster! What am I going to do?
Jude: Settle down man, don't get your dick in a knot.
by Betty C and Betty Jo February 26, 2008
An excessilvely pissed off guy
Mike: Ethan's car got towed
Joey: Mannnn, that guy's gonna really have his "dick in a knot"
by Manga4Lyfe October 16, 2010
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