An unusually incurable disorder in which the infected derp uncontrollably and prevents them from being a functional member of society or something of that nature.
Jeeze, that person can't do anything right they must have derpatitis! -Dr. Adkins.
The condition arising when one has contracted both herpes and hepatitis through overindustrious sexual activity. Note that this excludes, for example, simple cold sores and non-sexual forms of hepatitis such as hep A.
homeboy 1: "yo you better stay away from that bitch brah"
homeboy 2: "why brah?"
homeboy 1: "man that bitch is so nasty her herpes has hepatitis. she got herpatitis! shit!"
dumbass 1: "uuuugh look at brian that dude got herpatitis"
brian: "nah bro I got hep A from drinking the tap water."
dumbass 1: "well what about that shit on yo lip?"
brian: "man that shit is a cold sore. damn!"
When someone has the derps. If that is not clear enough, you probably have it. When someone is being stupid, ignorant, or just flat out annoying, they probably have derpititus.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.