'Defo' can be used in a variety of ways. It can be used jokingly, in moments of indignation, and even in a casual setting.
2. Come on Jill, let's hang out! Don't be defo
3. I throw my hands up in the air sometimes saying A-Yo I'm a defo!
2.an area where alcoholics and drug addicts are from
That guy is super faded, he must be from defo!
Damn Bryan you're fucked up like defo stats son!
Non-DeFo resident: "Uh, no."