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Someone who is overly prone or susceptible to entering a long term committed relationship with another. Usually used as a derogatory term towards someone who falls in love way too easily or needs to be in a relationship to feel whole.
(Roscoe Dash's lyrics in the song in the DJ Khaled song "Oh My") - "girl you the one, too bad I'm not a cuffer..."

One friend to another - "shut up man, you ain't no player... youz a damn cuffer. A sweetheart. A sucker for love..."
Cuffer by SillyBilly9000 December 13, 2018
Another term for jailbait. Going after this girl will likely get you arrested and in handcuffs.
Guy A: "I've got my eyes on the blonde baby-face in the shallow end of the pool"
Guy B: "Serious pal? She's a total cuffer"
Cuffer by Akaza April 16, 2013
A Policeman or Policewoman.
''watch it blad cuffer comin!''
Cuffer by sweet jesus April 14, 2006
someone who uses the end of their sleeve as a hankerchief
"eurr... look at that crust on his sleave, he's such a cuffer!"
cuffer by Jason K1 October 20, 2006
A person you would cuff in a relationship; someone you would keep forever.
Similar to the word keeper
Nick: "Dude Kate would make the perfect wife; she's a great cook, is good with kids, and has a nice body."
Greg: "Hell yeah dude, she's an absolute cuffer!"
Cuffer by rtsears August 8, 2018

Cuffer boy 

A pussy boy who falls for bitches easily and never listens to his boys adivice kisses every hoe he talks to but most of the time doesn't fuck them only the ones he cuff does he actualy fuck
Cuffer boy by Ghr April 14, 2015