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1.
When you introduce a friend from one group to a friend from another group, and they become autonomous friends, no longing requiring your services to hang out. Not necessarily a bad thing, but can be disastrous if left unchecked.
Dude 1: Dude, did you hear that Joe was hanging with Jane now?

Dude 2: Yeah dude. I introduced them a week ago and they don't even call me to chill anymore. Serious cross-pollination.
by Soren Santos September 11, 2006
 
2.
Cross pollination occurs when, during a threesome with one male and two females, the male has anal sex with one girl and then puts his penis in the other girls mouth. He then puts his penis in that girls ass and then into the other girls mouth.
John is having a threesome with Jane and Crystal. He puts his penis in Crystal's ass then into Jane's mouth. He then puts his penis in Jane's ass and then into Crystal's mouth thus causing cross pollination between Jane's ass and Crystal's mouth and Crystal's ass and Jane's mouth.
by Gmcd43 May 21, 2012
 
3.
To expell flatulence directly onto the skin or clothing of another person.
He lifted the small redneck behind his back and soiled his uniform using the cross-pollination technique.
by spankmasterflash 5000 September 23, 2010
 
4.
Figure A and B are brother and sister, or related in some way. Figure A dates or hooks up with Figure C while Figure B goes out or hooks up with figure D. Some time later, Figure C and Figure D hook up as well. This mixing of juices is called Cross Pollination, and is generally looked down upon in a modern day society.
Dude, they totally cross pollinated... cross Pollination is gross... I just really threw up a little in that cup.
by ottawabu April 21, 2009
 
5.
When you introduce a friend from one group to a friend from another group, and they become autonomous friends, no longing requiring your services to hang out. Not necessarily a bad thing, but can be disastrous if left unchecked.
Dude 1: Dude, did you hear that Joe was hanging with Jane now?

Dude 2: Yeah dude. I introduced them a week ago and they don't even call me to chill anymore. Serious cross-pollination.
by Soren Santos September 10, 2006