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1.
During vaginal intercourse, the penis is inserted into a woman's ass and then inserted back into her vagina; therefore, the penis takes the shit from her ass and gets it into her vagina.
Rick was so drunk the other night that his cock slipped out of what's-her-name's vagina and he put it in the wrong hole--her ass. After she complained, he put his dick back in her vagina and finished up. She got a yeast infection because that’s what happens when guys cross-pollinate.
by tonymarc May 16, 2009
 
2.
To switch back and forth between vaginal and anal sex.
I got drunk last night and let John cross-pollinate. I hope I don't get an infection!
by Hollylicious November 16, 2011