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1.
Pitch correction software specifically for vocals that makes up for a lack of natural singing talent. 90% or more of all "professional" recordings use this software.
An extreme example is that horrific Cher song from a few years back, and the Kid Rock song where is voice is all fucked up. Used in moderation it can hardly be heard except by a trained ear.
Remember before autotune, when singers could actually sing?

or

Man, that chick sings so bad not even autotune can fix it.
by BennyW February 01, 2007
 
2.
The software Katy Perry uses to make her albums bearably in tune.
"Dude, Katy Perry uses autotune a lot in her album. You can tell when you see her live.
by jahm3z April 29, 2009
 
3.
Someone who uses autotune to create a song. Frequently used by "rappers" but really shouldn't be rappers but should be known as a new genre called "Autotune"
Someone: "Did you hear T-Pain's new Rap CD?"
Someone else: "He isn't a rapper...Rappers bust flows and spit words to a beat, T-Pain is a singer that overuses autotune."
by Bullshit Rappers November 13, 2009
 
4.
A tool used to cover up the fact that you can't sing.
T-Pain uses Auto Tune because his voice sounds like a cat in a meatgrinder.
by A kid from Delbarton, WV April 30, 2010
 
5.
Autotune is simply a piece of technology made by the dark lord Lucifer to snare the souls of all man kind,since autotune was taken up by a Mr T-Pain people have been dick riding this software and selling their souls to the dark angel at the same time, much to the amusement of every Rock'n'Roll fan. Kanye West devoted an entire album(808 & Heartbreak) to this piece of shit and the gates of hell opened like Paris Hiltons devil snatch and ever since autotune has been a means to sell albums to teenagers begging to fit in to their 'click'. With a billion Chinese people in the world loving this crap im sure we will have to bear with it for years to come.God I only hope that I die before Nickelback start using it.
T-Pain: Yo,Kanye you heard of Autotune.
Kanye West: Yeah....
T-Pain:*autotune*So can you sing like a Robot?*autotune*
Kanye West:*autotune*Yeah, I can sing like a robot, ohwaaa.*autotune*
Record Label CEO: God, its so shit but it sells like hot cakes.I am most definitely going to hell.

Lucifer:They really don't make it difficult do they?.*Evil Laugh*
by Liaserg June 20, 2010
 
6.
-TPain's voice in songs
Is that autotune or Tpain? Both
by Joe1010101 April 27, 2010
 
7.
It is used to disguise inaccuracies and mistakes, and – due to its increasing use in modern music – has allowed many artists to produce more precisely tuned recordings. While Auto-Tune is only one out of many commercial pitch correction packages, auto-tune is frequently used in the media as a blanket term to describe any audio processing with a similar effect, perhaps because it was the first product allowing pitch correction in real time.
In the hit single lollipop, Lil Wayne used auto tune.
by dj32089 September 18, 2008