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1.
An expression of frustration indicating one has reached their quota of stupidity, rage, and/or overwork.
I got into another stupid argument with my ignorant assclown boss this morning. I've already had an assfull today -- I'm ready to go home and drink.
by turdrider November 16, 2011
 
2.
Someone with a big, huge ass.
Someone acting stupid and fooling around.
"Woah, stop being an assfull"
"You such an assfull"
by anaml February 02, 2008